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One of the most controversial subjects in relation to the Second Coming of our Lord Jesus, is whether or not there is a Secret Rapture of Christians seven years pr

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ior to His return.

We know from Paul’s writings that at the last trump, when the trumpet sounds the dead in Christ will rise first and those believers on earth wi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

l be changed in an instant and receive our new immortal bodies 1 Corinthians 15:51-53, “Behold, I show you a mystery; We shall not all sleep, but we shall all be c

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

hanged, In a moment, in the twinkling of an eye, at the last trump:for the trumpet shall sound, and the dead shall be raised incorruptible, and we shall be changed

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

For this corruptible must put on incorruption, and this mortal must put on immortality.”

This raises the question, if there had already been a Christian rapture

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

seven years earlier, why would Paul be telling them that he expects them to still be on earth (remembering that Paul did not know the timing of the Lord’s return a

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

d wrote with the expectation that perhaps it would be during his lifetime)?

Paul states clearly that these events takes place “at the last trump,” not seven years

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

before it. He shows that, “the trumpet shall sound.” So it will be loud, not quiet or secret.

Some teach that Jesus Christ will return secretly in the twinkling

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

f an eye, but Paul actually says it is the changing of the bodies of believers from mortality to immortality that happens in the twinkling of an eye. Therefore, 1

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

Corinthians 15:51-53 does not teach of Christians mysteriously vanishing at all. Rather, it reveals an extremely loud, audible return of Jesus Christ during the fi

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

al sounding of the last trumpet and the instant transformation of believers into their new immortal bodies at the end of the world.

Paul also wrote 1 Thessalonian

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

s 4:16 - 5:4 “For the Lord himself shall descend from heaven with a shout, with the voice of the archangel, and with the trump of God: and the dead in Christ shal

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

rise first: Then we which are alive and remain shall be caught up together with them in the clouds, to meet the Lord in the air: and so shall we ever be with the

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

Lord. Wherefore comfort one another with these words. But of the times and the seasons, brethren, ye have no need that I write to you. For yourselves know that the

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

day of the Lord so cometh like a thief in the night. For when they shall say, Peace and safety; then cometh sudden destruction upon them, as travail upon a woman w

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ith child; and they shall not escape. But you brethren, are not in darkness, that that day should overtake you as a thief”

So as well as again telling the people

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

hat they will be on earth when Jesus comes, he is also telling them that they should be ready for his return, so that it will not be unexpected the way it will be

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

for the unbelievers. It describes a loud audible return of the Lord and the Christians meeting him in the air. He says that Jesus comes down from heaven, true beli

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

vers are caught up together, and sudden destruction comes upon the lost. Again this does not depict a secret rapture in any way, and he is saying that the Christia

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ns will still be on earth at the final trump.

We need to study the Word of God so that we are prepared for what will happen in the final events of Earth’s history

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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