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We have read about the unemployment rate being high. Really anything around six percent is pretty good and it is less than that now acc

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ording to the statistics, but some politicians say it is terrible and others say it is reasonable. It depends upon which side of the is

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

le you sit.

Our Washington geniuses claim they are working on finding more employment. We have lost 2.7 million jobs over the last 3 y

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ears. That doesn’t matter if you are NOT one of them. Finger pointing by everyone in our capitol blames “the other guy”, but especially

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

China and India. The total of jobs going overseas is only 300,000 out of the 2.7 million. Where did the other 2.4 million jobs go?

As

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

the economy slowed down in 2000 due to the increasing interest rates companies had to do something to keep profits. The work week coul

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

d be shortened if you did not have a production line, but that doesn’t work for service businesses. All unnecessary workers were laid o

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ff. As business contracted machines became idle and more people were chopped. But that was not enough. More production efficiencies wer

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e put in place so that fewer workers would be able to turn out the same amount of goods.

Production dropped from the 92% to about 75%

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

of capacity today. When a company has 100 machines and only 75 of them are producing there is no incentive for management to buy more m

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

chines.

Sir Alan can try to stimulate further by lowering rates even more, but how much below 1% can you go? He could buy long-term bo

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

nds to further reduce rates to continue to stimulate the housing market, but financial stimulus does not create wealth. The banks borro

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

w from the Fed at 1% to buy long-term government bonds that yield 4.2%. If I were a banker and could lock in 3.2% with no risk why shou

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ld I make loans to businesses? And beside that I can fire all my loan officers to save more money.

But we need more employment. How? T

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

he Federal government is hiring more people every day. These are new jobs, BUT they do not contribute to the overall economy. In fact e

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

very new government worker is another tax. In a factory a worker turns out products that adds to what is called Gross Domestic Product.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

A government worker turns out nothing and adds zero to the GDP and even has to give back part of his salary in taxes. The IRS takes in

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

the money, gives it to Congress who creates burocracies that hire people to recirculate the cash. Every government worker is a tax.

T

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

his makes the employment numbers look good, but adds nothing to our economic production. It is a way to keep money flowing. It puts mon

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ey in peoples’ pockets that keeps us marching in place. Until real productive job are created by business we are just fooling ourselves

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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