Just Answers - Communications

This begins a series of articles on one of the greatest and most important inventions of all time, the telephone.

The period was the 1870s. During that tim

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

e two inventors by the name of Elisha Gray and Alexander Graham Bell both independently laid out the design for devices that could allow people to transmit t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

heir speech by electronic means. The two of them rushed their inventions to the patent office, literally within hours of each other. Never before in histor

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

y had this happened and it hasn't happened since. It turned out that Bell patented his phone first and was given credit for the invention. Gray and Bell th

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

n got into a very famous legal battle over this patent which Bell ultimately won. So right from the beginning, history could have turned out differently.

T

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

he telegraph, which was already in existence at the time, was a wire based system just like Bell's telephone. In reality, Bell's success with the telephone

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

was from his attempts to actually improve the telegraph. The telephone was just an accident from these attempts.

When Bell began working with and experimen

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ing with electrical signals, the telegraph had already been in existence for over 30 years and was an established means of communication. And even though, f

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

or the time, it was a fairly sophisticated system using dot and dash Morse code, the telegraph was still limited to sending just one message at a time and wa

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s very slow. It was Bell's understanding of sound and of music that made it so that he was able to visualise sending multiple messages over the same wire at

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

the same time. Even though the idea of a multiple telegraph had existed for quite some time, Bell argued that his musical and harmonic idea was the best sol

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ution to this problem. He said that different notes could be sent over the telegraph at the same time if they were of different pitch.

It wasn't until 1874

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

, in October of that year, that Bell's research had gotten to the point where he could tell his future father in law, attorney Gardiner Hubbard, about his id

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ea of the multiple telegraph. Hubbard was against the total control that Western Union telegraph had over the industry and thought that this invention had t

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

e potential for breaking up such a powerful monopoly. Because of this, he gave Bell the financial backing that he needed. It was at that time after receivi

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ng the money that Bell began work on his multiple telegraph. What he didn't tell Hubbard was that he and a man by the name of Thomas Watson, an electrician

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

he had hired to help him, were also working on an idea that Bell had come up with that summer. The idea was to create a device that could transmit speech el

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ctrically. The reason that Bell didn't tell Hubbard about this idea was twofold. For one thing, he didn't want to get him excited about something that quit

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e possibly wouldn't happen. Also, he didn't want to risk the possibility of losing backing because he was working on other things besides what they agreed o

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

n. So he kept this a secret.

In the next part in this series we'll pick up with Bell's meeting with the director of the Smithsonian Institute, Joseph Henry

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Every aspect of life has “perfect timing” at some point, if you are lucky you may have the opportunity of getting your adjustable rate mortgage at that time. What this means, though, is that interest rates are currently at an all time high and most people will not want to commit to this rate for the life of the loan.

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