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RAID is the short form of Redundant Array of Inexpensive Disks, where Inexpensive is often replaced with Independent. A few years back when the disks had less stor

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

age capacity with expensive prices, a couple of disks were mounted to create a larger virtual disk, and it was much more logical and easily administered.

All the

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

disks are all placed in a confined area and if one disk crashes then a very useful amount of data can be lost. In order to avoid this is a technique called ‘Mirror

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ing’ is taken into consideration. The data from all the disks is copied to another bulk of disks, so that if there is any corrupted disk then it would be replaced

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

with its mirror disk. This is done for the complete integrity of your mission-critical data.

RAID Types

Although there are many types of RAID arrays, but the one

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

s explained below are the important of all.

Concatenation:

This type of RAID array is called ’Simple’ RAIDs. It is a group of disks that are connected togeth

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

er tightly. Data is distributed in a linear pattern on the disk. Data is written a sequential order i-e, first disk is filled and then the text gets written on to

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

the next disk and so on. All this is done by the volume manager, who is the in charge of the RAID. If we have less data as compared to the total size of all the d

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

isks combined then it is useless for us.

RAID-0:

It is also known as ‘striping’. Striping is much similar to concatenation, but data processing of RAID-0 is

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

much better than its predecessor. Whenever we write some data it gets stored across all the disks. So when there is a request for data retrieval or placement it is

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

executed much faster. Stripe width and columns are the things which make this type important.
-Stripe Width: It specifies the amount of data to be written on

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

one particular disk.
-Column: It refers to each disk. A major flaw of RAID-0 is that if a single disk crashes than the whole system can collapse, since the

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

data is stripped across all the disks.

RAID-1:

This type of RAID is called ‘Mirroring’. Though it’s not actually a RAID but sure is an important component o

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

f RAID. The logic behind this technique is to create a mirror image of your RAID. So that if a particular disk crashes, then the mirror will play its part. Mirror

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ing is an excellent way of protecting the business critical data, but it comes for a good amount of money.

RAID-0+1:

This type combines Stripping and Mirrori

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ng together. We place a bunch of disks, which acts like mirrors to save the stripped data. One important thing to know is that the mirror has to be the same type o

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

f RAID as the original RAID. If we want to make a mirror copy of the simple RAID, then our mirror will be simple RAID and vice versa.

RAID-5:

RAID-5 is the b

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

est solution for increasing disk space and disk redundancy by leaps and bounds. It is similar to RAID-1 as it contains columns and stripe-widths. The difference ap

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

pears when we write data. The data is written to the multiple disks at the same time, parity is also written along the data.

So even if a single disk fails then n

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

o need to worry since the data is saved on the remaining disks. Though we get quite pleased with the results but all goes in vain when we think about I/O bandwidth

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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