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The cost of new housing in San Diego County has more than tripled during the last 10 years. The San Diego Hous

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ing Commission reports the average price of a new home has jumped from almost $245,884 in 1996 to $861,759 in 2

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

006. As property values in the area reach the million dollar mark, prospective homeowners face a new breed of

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

loan…the jumbo or super jumbo mortgage.

Jumbo and Super-Jumbo mortgages do not conform to the Fannie Mae feder

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

al mortgage guidelines. Those guidelines limit the amount of mortgages at $417,000. Also known as non-conform

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ing loans, these loans don’t have to meet standard mortgage rules.

In an inflated housing market such as San D

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

iego County, some homeowners need options to keep the monthly mortgage payment low, while purchasing the home t

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

hey need.

An $850,000 home financed using a standard 30-year fixed rate mortgage, with 20% down, would come wi

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

th a monthly payment of more than $5,000. If the price seems high, the mortgage industry has some options for

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

prospective homeowners to keep payment lower.

A payment option ARM has an initial period of fixed rate interes

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

t, then the loan converts and the interest rate rises or falls according to one of the banking indexes, such as

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

COFI, LIBOR or MTA. A built in margin is added to the index rate to determine the interest rate. These loans

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

usually have four payment options each month, the standard 30-year or 15-year pay-off rate, the minimum paymen

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t option, and an interest only option.

The homeowner chooses each month how much payment they want to make. T

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

he minimum payment option doesn’t pay all of the principal or interest, and actually adds to the balance of the

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

loan, known as negative amortization. Sounds scary to some people, but if you make 5 years worth of minimum p

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ayments and your home’s value triples, the equity could make up the difference.

Another option is the interest

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

only loan. These loans allow homeowners to pay the interest amount only for a specified time period…then the

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

loan converts to a fully amortized loan. Again, if the home’s value increases, the homeowner is in good shape.

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

But if the home’s value doesn’t jump high enough, they could face some stiff payments when the loan converts.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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You just started your business and am trying to find clients. You do have a few but you want to obtain steady clients so you will always be busy. After all, that is the name of the game when you run a business – profits.

Whenever home owners require cash for any project they can access the equity of their homes in the form of a loan. This is the actual value a home owner has paid off on the mortgage loan and this is the value that belongs to the owner. The banks lend this amount back to the home owner with interest and bank charges are added. This loan is secured against the home which safeguards the lender.

For those who just want to learn more before getting a quote or changing their current policy.

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