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Bulgaria has attracted a lot of attention over the last two years, as foreign buyers and inves

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

tors flock to its emerging property market. In 2004, foreigners invested over Euro 500 million

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

in Bulgarian property, compared to Euro 98 million in 2003. Frequently listed in the top 20

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

places to buy a foreign property, Bulgaria is now firmly on the property investment map.

With

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

EU entry forecast for 2007 investors are keen to buy into the Bulgarian market to reap the in

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

evitable rewards of capital appreciation and establish a rental income in a country that has d

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

monstrated increasing tourism over the last few years. In the first 6 months of 2005 alone, o

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ver 2.7 million tourists visited Bulgaria; with a 42% increase in the number of British touris

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ts. By 2020 the World Trade Organisation has predicted that the number of foreign tourists vi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

iting the country will increase to 10 million.

The most popular regions for foreign property

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

investors can be broadly categorised into 3 sectors: the Black Sea Coast, Sofia and the mounta

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

in ski-resorts. Other buyers are attracted by the old houses inland that can start from as li

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

tle as ?1,700 and the medieval charm of picturesque cities and villages like Veliko Turnovo, A

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

rbanassi and Tryavna in central Bulgaria. Enjoying over 300 days of sunshine a year, boasting

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

a coastline that stretches over 380km, spectacular mountains, eco-tourism and some of the mos

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

affordable property in Europe, there is no wonder that Bulgaria is attracting such interest.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Property prices in some regions have doubled in the space of the last two years alone – though

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

new apartments on the coast are still available from as little as ?20,000.

Despite recent ba

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

press about developers and estate agents in Bulgaria over-estimating rental returns and exagg

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

erating capital growth rates, Bulgarian property remains under-valued and is a good investment

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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