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Okay, let's take a look at the typical payout options:

Full P

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

urchase - The investor buys the entire note. This alleviates t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

he seller of the responsibility to collect payments in the fut

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ure.

Straight Partial - The investor purchases a predetermine

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

number of payments in order to meet the seller's cash require

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ments. After the last payment of that predetermined term ends,

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

the balance on the note reverts back to the seller.

Reverse

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

Partial - The seller receives a lump sum and continues to rece

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ve the full payment amount for a specified period of time. Thi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s solution is appropriate when the seller needs a large amount

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

of cash at closing but also wants to receive the monthly paym

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ents for a while.

Split Payment - The investor purchases half

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

of the seller's monthly payment; the seller continues to recei

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ve the income from the other half.

Balloon Only - The investo

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

r purchases only the balloon due at the predetermined date on

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

the promissory note. This alternative works in situations wher

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

the seller needs some cash at closing but doesn't want to wai

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

t 30 years to collect the balance.

So, as you can see, you do

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

not have to sell your whole note. There are benefits for each

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

option. It just depends on what works best for your situation

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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