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Until a few years ago, Bulgaria was relatively unknown to the property investment market and yet today is drawing in more and more bargain-property hunting Brits, with many people keen to buy before

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

they’ve even visited this diverse country.

Situated in the heart of the Balkans, on the crossroads between Europe and Asia, Bulgaria has an enchanting mix of sandy beaches and seaside resorts, snowy

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

mountains boasting intricate ski slopes and breathtaking views, and rugged countryside for those who enjoy being at one with nature, fishing and hunting are also popular activities here.

Described

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

y some as the new Costa Del Sol, Bulgaria is also praised for it’s beautiful countryside, historic towns and un-compromised rural traditions.

A Varied Climate

Bulgaria has a temperate climat

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e with hot, dry summers and cold, damp winters. The Danube River runs through the country and its plains are open to the extreme conditions of central Europe, whilst the Rodopi Mountains form a barr

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

er to the Mediterranean warmth of the Aegean Sea.

The capital Sofia, situated in the west of the country, can generally reach temperatures of 28oC in July and August and 3oC in December to February.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Rainfall is highest in the mountain ranges and heavy snowfall is a strong feature of the winter. Along the black sea coast, a popular destination for holidaymakers, temperatures range from 1oC to

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

6oC in January, and 19oC to 30oC in July. The climate makes Bulgaria a great country for both summer & skiing holidays allowing you to virtually cover the whole year in your Bulgarian investment port

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

olio.

Awakening Eastern Europe

Whilst property prices reached a stagnate high in the popular holiday spots of Spain, Italy and France, Eastern Europe was awakening and the investment potenti

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

al in these former eastern block states was uncovered. The fast-growing economies of countries such as Latvia Lithuania and Estonia began appearing on the radars of investment-driven buyers when the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

joined the European Union in 2005. With Bulgaria set to join the EU in 2007, investors were able to take knowledge from the surrounding countries’ economic growth patterns and exploit the early bar

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

gains.

First the country experienced an influx of foreign investment and workers, which still today continues and who stimulated a demand for new properties. Secondly, a recent increase in affluenc

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e and the gradual emergence of a professional middle-class has fuelled the development of a stronger local market equipped to support the country’s investment magnetism. It’s predicted that a steady

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

rise in demand will continue over the next 2-4 years and one reason for this is the increasing popularity in mortgages, a concept relatively unknown in Bulgaria until recently. Now a widening variet

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

y of banks and other lending institutions are offering mortgage products to the local population, allowing them to own their own homes. Also firms such as Conti Financial Services in the UK are offe

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ing mortgage-style loans to foreigners interested in buying property in Bulgaria. However, with property and land prices in line with the current local economy in many areas, there is many a bargain

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

still to be found for the cost of a small car in the UK.

The emerging property market in Bulgaria also began attracting holiday-home buyers who could no longer afford the inflated prices of Europea

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

n countries closer to home. More airlines began adding Bulgaria to their flight itinerary making the country more accessible. At the same times holiday resorts of the black sea coast were becoming

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ore established and ripe for exploration by people from all over the world after an alternative to their usual holiday destination.

So with Bulgaria’s diverse landscape and developing infrastructure

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

proving an attractive prospect for the acute investor as well as the holiday home seeker, its no wonder this magnetic mix of old tradition and modern bustle still has many profitable miles in it yet

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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