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Getting an appraisal on a home is a fundamental aspect of making a purchase. While appraisals are cer

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

tainly helpful, you should not put too much stock in them.

Don’t Rely Excessively On Appraisals

An

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

appraisal is a valuation of a property by an independent appraiser. The appraiser does an evaluation

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

f the home, considers the home in comparison to others of comparable type and so on. Once completed,

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

the appraiser then issues a written appraisal value of the home. Many homebuyers make the assumption

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

he appraisal is the true value of the home both now and in the future. This can be a dangerous assump

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

tion.

First, appraisals are limited by something known as a moment in time. The appraisal done today

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

may not be entirely relevant a month or two later. If a property has been on the market for a few mo

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

nths, the appraisal may not reflect a slowing market. This, in turn, means the appraised value is act

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ally higher than the current market will support. Homebuyers run into problems when this occurs becau

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

se they put too much value on the appraisal. A seller will often list the home below the appraised am

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ount and homebuyers will think they are getting a deal. In reality, they are not and may actually be

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

aying more than a new appraisal would support. The older the appraisal, the less value you should put

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

into it.

Most homebuyers assume an appraiser inspects the home for defects and discounts the value

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

f the home accordingly. This is not really the case. An appraiser is not really doing a critical home

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

inspection. In fact, the appraiser contract and/or report usually contains a long disclaimer whereby

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

the appraiser covers his derriere by noting he assumes the property is in good condition and isn’t li

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

able if it is not. Obviously, that should scare you. This, of course, is why you should insist on a h

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

me inspection for any property you make an offer on.

An appraisal is a solid part of the equation wh

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

en considering a home purchase. It is not, however, the piece de resistance when valuing the property

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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