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The first set of charts include an SPX six-month daily chart that shows a W-pattern and a somewhat bullish inverse head & shoul

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ders with the neckline at 1,290. SPX has generally held 1,290, along with the 10-day MA, over the past seven trading days, in t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e belief a new high (above 1,326) will be reached.

The four charts below SPX are same period charts of the Transport Index, Ut

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

lity Index, Dow Industrials, and Nasdaq. The Transport Index failed to join the SPX rally after completing the double-top in ea

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ly-July, while the Utility Index made new highs. The arrows in the Dow Industrials chart show almost a perfect W-pattern, and a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

break above 11,250 resistance, which has held recently. Nasdaq continues to underperform.

There are many mixed signals in the

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

first set of charts, including a bullish MACD, and bearish volume. Moreover, the SPX 200-day MA continued to rise over the stee

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

fall and volatility, which is bullish. Furthermore, the bond market rally (not shown) has sent the 10-year bond yield 45 basis

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

points below the Fed Funds Rate, which is bearish (i.e. inverted yield curve). Some short-term technical indicators (not shown)

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

suggest SPX 1,290 will not hold and a pullback, e.g. to 1,275, will take place next week. After a pullback, SPX may rally agai

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

.

The second set of charts show intermediate-term technical indicators remain bullish. However, a trend reversal may take plac

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

within three weeks. NYSI has made lower highs, while SPX has made higher highs over the cyclical bull market. However, NYSI is

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

nearing the (gray) downtrend line. Also, below the NYSI and SPX comparison chart are the NYMO 50 and 20 day MAs, which are near

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ing tops. However, the CPC 50-day MA remains bullish (i.e. falling from an all-time high).

It's uncertain if SPX will rise to

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

new high over the next few weeks. Nonetheless, a trend reversal may take place in early or mid September, after the Labor Day

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

oliday a week from Monday (September 4th), perhaps around the 9/11 anniversary. Before the 1987 crash, the Dow Industrials also

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

created a W-pattern; click link http://www.lope.ca/markets/1987cr

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ash/ Currently, SPX is in the second longest period in history without at least a 9% pullback. Also, there's a great deal

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

f uncertainty about the economy. So, there could be some big moves, both up and down, over the next two months.

Free charts av

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ilable at http://www.peaktrader.com Forum Index Market Forecast category

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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