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Growth of China, India and the Asian region creates investment opportunity in these markets.
Energy demand will continue to grow; supply is not growing hence energy prices will rise.
Non-U.S. do

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

llar based currencies will continue to appreciate.

Demand for global financial services will grow rapidly.

Industrial metals and precious metals will be needed to further global growth. Supply is stagna

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

t and demand is rising, hence prices will rise.

Transportation equipment is important for this growth to continue.

CHINA TO ALLOW MORE INVESTORS TO OWN STOCKS ABROAD...BULLISH FOR ASIA, ESPECIA

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

LLY HONG KONG AND SINGAPORE We anticipate that a great deal of Chinese capital will gradually find its way into the regional stock markets of Asia; first into Hong Kong, then into other Chinese language market

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

like Singapore, and eventually into the Philippines, Indonesia, Vietnam, etc. We own Singapore and Hong Kong companies for our clients and plan to use market pullbacks to add to these positions. In our view, this grow

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

th will continue for many years and is not for a short-term trend. AREAS OF FOCUS IN HONG KONG AND SINGAPORE In Hong Kong, we are focused on companies which are property developers in Hong Kong, who ha

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e also made big commitments to property development in China. Within Singapore, we continue to like many industries, especially financial services. Singapore has a well educated work force, a good port system, stable a

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

nd efficient non corrupt government, good courts, excellent legal and accounting framework, and a pro business environment with low taxes. We believe Singapore will become the Asian financial capital as London is for E

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

rope, and New York is for North America.

WHAT WE ARE EXPERIENCING IS A LONG-TERM TREND, ASIAN GROWTH WILL CONTINUE FOR MANY, MANY YEARS Not since the industrial revolution of Europe has there been suc

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

h far reaching change in the global economic background.

THIS IS AN OLD THEME FOR US WE HAVE BEEN SAYING THESE THINGS FOR OVER 5 YEARS, AND OTHERS ARE FINALLY GETTING ON THE BANDWAGON In a major repor

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

to clients this week, Morgan Stanley estimates that 30 million Asian people per year, for the next 20 to 25 years, will move from the countryside into Asian cities.

Their analysts predict that 17 million per year in

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

hina, and 13 million per year in other Asian countries like India will make the journey. They correctly point out that this huge influx will be due to rising standards of living in Asia, and that immense infrastructure

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

spending will be required to manage this transition.

These articles are for informational purposes only and are not intended to be a solicitation, offering or recommendation of any security. Guild Investment Manageme

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t does not represent that the securities, products, or services discussed in this web site are suitable or appropriate for all investors. Any market analysis constitutes an opinion that may not be correct. Readers must

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

make their own independent investment decisions.

The information in this article is not intended for distribution to, or use by, any person or entity in any jurisdiction or country where such distribution or use woul

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

be contrary to law or regulation, or which would subject Guild Investment Management to any registration requirement within such jurisdiction or country.

Any opinions expressed herein, are subject to change without n

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

otice. In addition, there are many market, currency, economic, political, business, technological and other risks that are beyond our control. We make reasonable efforts to provide accurate content in these articles; h

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

wever, some content and some of the assumptions, formulas, algorithms and other data that impact the content may be inaccurate, outdated, or otherwise inappropriate. In addition, we may have conflicts of interest with

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

respect to any investments mentioned. Our principals and our clients may hold positions in investments mentioned on the site or we may take positions contrary to investments mentioned.

Guild’s current and past market

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ommentaries are protected by copyright. Apart from any use permitted under the Copyright Act, you must not copy, frame, modify, transmit or distribute the market commentaries, without seeking the prior consent of Guild

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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