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In more recent times I’ve developed a keen fascination towards the word “denial”. I've noticed its increasing prevalence throughout the mid 1990’s when psychological phrases previou

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

sly reserved only for use by professionals became commonplace in the home, and one of the words that was at the forefront of this explosion was the word, you guessed it, “denial”.

N

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

wadays the word is liberally tossed around and has such broad application being used from anything ranging to a middle aged guy carrying a little extra weight around his middle think

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ng he looks great in a Baywatch cherry red speedo (I shudder upon writing this) all the way to the other side of the spectrum of a bad tempered woman refusing to admit she has anger

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

issues.

According to my trusty companion the Encarta World English Dictionary, the word “denial” means “a state of mind marked by a refusal or inability to recognize and deal with a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

serious problem” and in any good rehabilitation program whether it be alcohol or drug in nature, a patient cannot get better unless they first admit to, or own the fact that they are

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

an addict, and until they recognize this they can never be rehabilitated. In other words, if they remain in a state of denial, they will never get better.

So, just how many of us a

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

re comfortably riding on the “denial” wagon? Could we possibly be in denial about our current debt level?

I know what you’re thinking, “debt and drugs are like chalk and cheese, th

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

y do not merit the same weight”, while this maybe true in the “harmful” sense of drugs, if allowed to, the denial of our debts can have detrimental effects of their own if we don’t g

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

t them under control.

How Can I Know If I’m In Debt Denial?

1. If you have no idea how much you owe, even a ballpark figure. How are you expected to get out of debt if you don’t k

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ow the extent of it? It’s the equivalent of slowly sinking on capsizing boat while your happily sipping pina colodas. Sooner or later the boat will go down if you don’t know the ex

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

tent of the damage and repair the leak.

2. When you throw out your credit card statement before opening it or never open it at all.

3. Think that you’ll be fine continuing to pay t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e bare minimum even if you’re no meeting your current financial commitments.

4. Have more than 3 credit cards and don’t hesitate in getting another one even when you’re struggling t

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

keep up payments for existing cards.

5. Here’s a biggie, when your spouse doesn’t know the true extent of your debt, if you feel the need to keep secrets for fear of reprehensi

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

on then you may have a serious problem you need to deal with.

Cure for Debt Denial – Rip That Band Aid Off

When I was a child, whenever I had a sore, my mother taught me to rip the

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

band aid off in one go, it was less painful than to pick at the edges and tug slowly away at it.

I’m giving you the exact same advice, go ahead and rip that band aid off in one fell

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

swoop, face the debt, embrace it by resurrecting those credit card statements from the dusty shoe boxes, call your bank, lending institution and creditors to get the full picture of

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

your current situation.

Negotiate favorable terms and conditions to pay back your debts and honor them. Banks and lending institutions love it when you make an honest effort to pay

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

them back plus it comes with the added bonus of strengthening your credit rating just by improving the regularity and consistency of your payments.

No matter how traumatizing this m

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

y be at first just remember this is a hug step in the right direction because you will never be free of debt if you have no idea how deep in you really are. Knowledge truly is power

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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